Tofranil is used to treat depression. It is a member of the family of drugs called tricyclic antidepressants.

Tofranil is also used on a short term basis, along with behavioral therapies, to treat bed-wetting in children aged 6 and older. Its effectiveness may decrease with longer use.

Some doctors also prescribe Tofranil to treat bulimia, attention deficit disorder in children, obsessive-compulsive disorder, and panic disorder.