Propine is used to treat chronic open-angle glaucoma, the most common form of the disease. In glaucoma, the fluid inside the eyeball is under abnormally high pressure, a condition which can cause vision problems or even blindness.

Propine belongs to a class of medication called "prodrugs," drugs that generally are not active by themselves, but are converted in the body to an active form. This makes for better absorption, stability, and comfort and reduces side effects.