Imodium is prescribed for the control and relief of symptoms of diarrhea not known to be caused by a specific germ, and for diarrhea associated with long-term inflammatory bowel disease. This drug is also prescribed for reducing the volume of discharge from an ileostomy (a surgical opening of the small intestine onto the abdominal wall for purposes of elimination).

Some doctors also prescribe Imodium, along with antibiotics such as Septra or Bactrim, to treat traveler's diarrhea.