Enbrel is used to treat the symptoms of moderate to severe rheumatoid arthritis when other drugs have proved inadequate. It is the first in a new class of drugs designed to block the action of tumor necrosis factor (TNF), a naturally occurring protein responsible for much of the joint inflammation that plagues the victims of rheumatoid arthritis.

In clinical trials, Enbrel provided the majority of patients with significant relief. In addition, it can be taken along with other drugs commonly used to treat rheumatoid arthritis, including methotrexate (Rheumatrex), steroids such as hydrocortisone and prednisone, nonsteroidal anti-inflammatory drugs such as Motrin and Naprosyn, aspirin, and other pain-killers.