Anafranil is prescribed for the treatment of major depression--that is, a continuous depressed mood that interferes with everyday life. The symptoms of major depression often include changes in appetite and weight, difficulty sleeping, loss of interest in pleasurable activities, constant fidgeting or a slowdown in movement, fatigue, feelings of guilt or worthlessness, difficulty concentrating, slowed thinking, and suicidal thoughts. Anafranil is thought to work by adjusting the balance of the brain's natural chemical messengers, especially norepinephrine and serotonin Anafranil makes some people drowsy or less alert, and may affect judgment and thinking. Don't drive or participate in any hazardous activity that requires full mental alertness until you know whether Anafranil has this effect on you.